
Advair (generic name: fluticasone propionate/salmeterol xinafoate; also known in some markets as Seretide, Seroflo, Viani, Adoair, or ForAiris) is a fixed-dose inhaled corticosteroid (ICS) and long-acting beta2-agonist (LABA) combination used for the maintenance treatment of asthma and chronic obstructive pulmonary disease (COPD). By pairing a potent anti-inflammatory medicine with a long-acting bronchodilator, Advair helps reduce airway swelling and keeps bronchial muscles relaxed, improving day-to-day breathing and reducing flare-ups. For quick relief of sudden symptoms, a short-acting rescue inhaler such as Ventolin (albuterol) should be used alongside Advair as directed by your clinician.
Advair is intended for long-term control, not for the immediate treatment of acute bronchospasm. Patients should use it consistently, usually twice daily about 12 hours apart, to maintain steady symptom control and reduce the risk of exacerbations.
What Advair Is Indicated For
- Maintenance treatment of asthma in patients 4 years of age and older (specific age ranges depend on the device and strength).
- Maintenance treatment of airflow obstruction and reduction of COPD exacerbations in appropriate adult patients. In COPD, Advair helps improve lung function and reduce flare-ups when used regularly.
Advair targets both core drivers of obstructive airway diseases: airway inflammation (managed by fluticasone) and airway constriction (managed by salmeterol). This dual mechanism supports better symptom control, fewer nighttime awakenings, improved exercise tolerance, and a lower risk of severe exacerbations over time.
Forms, Devices, and Strengths
Advair is available in multiple device formats and strengths. Availability can differ by country.
- Advair Diskus (dry powder inhaler, DPI): Delivers powder via breath activation, typically 60 doses per inhaler. Common strengths (fluticasone/salmeterol per dose): 100/50, 250/50, 500/50 micrograms. In many regions, Diskus is indicated for asthma (ages 4+) and COPD (adults). For COPD, 250/50 is commonly used.
- Advair HFA (metered-dose inhaler, MDI): A pressurized inhaler delivering aerosolized medication; 120 actuations per canister. Common strengths (fluticasone/salmeterol per actuation): 45/21, 115/21, 230/21 micrograms. Advair HFA is generally indicated for asthma maintenance; check local labeling for age restrictions (commonly 12+).
- Rotacaps/capsule-based inhalation: In some markets outside the U.S., capsule-based fluticasone/salmeterol products are available. If using a capsule device, follow the specific instructions for puncturing and inhaling each capsule’s contents with the paired inhaler.
Your clinician will select a device and strength based on your age, diagnosis, baseline control, and lung function. The goal is to use the lowest effective dose that maintains symptom control and minimizes side effects.
Recommendations
Use Advair exactly as prescribed. Consistency is essential for controlling chronic airway inflammation and preventing flare-ups.
- Typical dosing: One inhalation twice daily, about 12 hours apart, in the morning and evening. Do not exceed the prescribed dosage.
- Rinse, gargle, and spit after each use: This reduces the risk of oral thrush (yeast infection) and hoarseness by removing residual steroid from the mouth and throat.
- Not a rescue medication: Do not use Advair to relieve sudden wheezing or shortness of breath. Always keep a fast-acting rescue inhaler (e.g., albuterol/Ventolin) on hand and follow your asthma or COPD action plan.
- Onset of benefit: Some improvement may be noticed within days, but the full effect may take 1–2 weeks or longer. Keep using Advair as directed even when you feel well. Do not stop abruptly without medical guidance.
- Missed dose: If you miss a dose, take it as soon as you remember unless it is close to your next scheduled dose. Do not double up.
- Do not use with another LABA: Avoid duplicating therapy with medications containing formoterol, vilanterol, or other LABAs.
Proper inhaler technique matters. Before first use, a clinician, pharmacist, or respiratory therapist should demonstrate the correct method for your device. Technique refreshers during follow-up visits help maintain control and reduce side effects.
Using Your Inhaler: Technique Tips
- Advair Diskus (DPI)
- Open the device as instructed until you hear a click to load a dose. Keep it level; do not shake.
- Exhale fully away from the device. Do not exhale into the mouthpiece.
- Seal lips around the mouthpiece and take a strong, steady, deep breath to draw powder into your lungs.
- Remove the device and hold your breath for up to 10 seconds if comfortable, then exhale slowly.
- Close the Diskus, rinse and spit. Do not wash the Diskus; keep it dry.
- Advair HFA (MDI)
- Shake well before each use. Prime the inhaler per instructions when new or if not used for a period.
- Exhale fully away from the inhaler. Place the mouthpiece in your mouth and seal lips.
- Begin a slow, deep inhalation and press the canister once to release a dose as you breathe in steadily.
- Hold your breath up to 10 seconds if possible, then exhale slowly.
- Wait about 30 seconds if a second puff is prescribed, then repeat. Rinse and spit afterward.
- Spacers are generally not used with Advair HFA unless specifically advised; follow device labeling and clinician guidance.
How Advair Works
- Fluticasone propionate (ICS): Reduces airway inflammation by suppressing inflammatory mediators and cytokines, lowers airway hyperresponsiveness, and decreases mucus production over time.
- Salmeterol xinafoate (LABA): Provides prolonged bronchodilation (approximately 12 hours) by stimulating beta2 receptors in airway smooth muscle, helping keep airways open and reducing symptoms such as wheeze and chest tightness.
The combination is synergistic: sustained bronchodilation improves distribution of inhaled steroid deeper into the lungs, while the steroid mitigates inflammation that drives symptoms and flares. In asthma, this pairing reduces exacerbations and nighttime symptoms. In COPD, it improves lung function and lowers exacerbation risk in suitable patients.
Precautions
Before using Advair, tell your clinician if any of the following apply:
- Allergies: Hypersensitivity to fluticasone, salmeterol, or milk proteins/lactose (some dry powder devices contain lactose and may be contraindicated in severe milk protein allergy).
- Current respiratory medications: Using another LABA (e.g., formoterol, vilanterol, olodaterol) or duplicate ICS can increase risk of side effects.
- Cardiovascular conditions: Arrhythmias, coronary artery disease, hypertension, or history of QT prolongation can be affected by beta-agonists.
- Infection risk: Active infections, untreated oral thrush, or exposure to chickenpox/measles. Inhaled steroids can modestly increase susceptibility to infections.
- Tuberculosis, fungal, viral, or bacterial infections: ICS may worsen or mask infection. Screen and treat appropriately.
- Endocrine and metabolic conditions: Diabetes (LABAs and steroids can affect glucose), thyroid disorders, adrenal suppression history.
- Bone and eye health: Osteoporosis, low bone mineral density, glaucoma, or cataracts can be influenced by long-term corticosteroid use.
- Seizure disorders or hepatic impairment: May alter risk/benefit or require closer monitoring.
- Pregnancy and breastfeeding: Discuss potential benefits and risks; use the lowest effective dose. Many clinicians continue ICS/LABA when needed to maintain maternal respiratory health.
Do not use Advair to treat acute bronchospasm. If you experience sudden breathing difficulty, use a rescue inhaler and seek medical care per your action plan.
Drug Interactions
- Strong CYP3A4 inhibitors (e.g., ritonavir, cobicistat, ketoconazole, itraconazole, clarithromycin): May increase systemic exposure to fluticasone, raising the risk of steroid-related side effects (adrenal suppression, Cushingoid features). Avoid or monitor carefully.
- Non-selective beta-blockers (e.g., propranolol): May blunt the effect of salmeterol and provoke bronchospasm; use cardioselective agents with caution if necessary.
- Diuretics (especially loop and thiazide diuretics): Combined with beta-agonists, may increase risk of hypokalemia; monitor electrolytes in susceptible patients.
- MAO inhibitors or tricyclic antidepressants: May potentiate cardiovascular effects of beta-agonists; use with caution.
- Other adrenergic agents or sympathomimetics: Can increase side effects such as tremor, tachycardia, palpitations.
- Strong CYP3A4 inducers (e.g., rifampin, carbamazepine): May reduce fluticasone effectiveness; monitor control and adjust therapy if needed.
Side Effects
Most side effects are mild and manageable with correct technique and dose optimization. Report persistent or severe reactions promptly.
- Common
- Hoarseness, throat irritation, cough.
- Oral thrush (oropharyngeal candidiasis). Rinse, gargle, and spit after each use to reduce risk.
- Headache, nervousness, tremor, palpitations.
- Less common to serious
- Pneumonia in COPD patients. Seek medical evaluation for fever, productive cough, chest pain, or worsening breathlessness.
- Paradoxical bronchospasm immediately after dosing. Discontinue and seek care if this occurs.
- Adrenal suppression, hypercortisolism, or growth effects in children with high or prolonged ICS exposure. Use the lowest effective dose; monitor pediatric growth.
- Glaucoma, cataracts with long-term corticosteroid use. Periodic eye exams may be recommended.
- Decreased bone mineral density over time; consider calcium/vitamin D and weight-bearing exercise as appropriate.
- Hypokalemia or hyperglycemia, particularly with high doses or interacting medications.
- Hypersensitivity reactions: rash, urticaria, angioedema. Seek immediate care if swelling or breathing difficulty occurs.
Regular follow-up with your healthcare provider helps optimize dose, review technique, monitor control (symptoms, rescue inhaler use), and detect side effects early.
Who Should Not Use Advair
- Patients with known severe allergy to any component, including milk proteins in lactose-containing DPIs.
- Patients whose asthma is adequately controlled on low-dose ICS alone may not require combination therapy; overtreatment can increase risks without added benefit.
- Use caution or consider alternatives in patients with unstable cardiovascular disease or significant arrhythmias.
Ingredients
Active ingredients: fluticasone propionate (inhaled corticosteroid) and salmeterol xinafoate (long-acting beta2-agonist). Inactive ingredients vary by device: lactose monohydrate (contains milk proteins) in Diskus dry powder; HFA inhaler propellant and excipients in Advair HFA. Check the patient information leaflet for a full list of excipients.
Monitoring and What to Expect
- Symptom control: Fewer daytime and nighttime symptoms, improved exercise tolerance, and reduced rescue inhaler use are expected within 1–2 weeks of consistent therapy.
- Exacerbations: Over months, many patients experience fewer exacerbations and urgent care visits.
- Objective measures: Peak flow tracking at home and periodic spirometry help assess response and guide dose adjustments.
- Follow-up cadence: Early follow-up after initiation or dose change (typically 4–6 weeks), then every 3–6 months, or sooner if control worsens.
Comparisons and Alternatives
Other ICS/LABA combinations include budesonide/formoterol (Symbicort), mometasone/formoterol (Dulera), and fluticasone furoate/vilanterol (Breo Ellipta). Each differs in device type, dosing frequency, onset of action, and approved indications.
- Advair (fluticasone/salmeterol): Twice daily. Salmeterol has a slower onset than formoterol and is not used for single-maintenance-and-reliever therapy (SMART).
- Symbicort/Dulera: Use formoterol, which has a faster onset, allowing SMART in asthma per some guidelines when appropriate.
- Breo Ellipta: Once-daily option for certain patients; check indications and patient preference.
- Generic/wider access: In many regions, fluticasone/salmeterol generics (e.g., Wixela Inhub) offer cost savings with comparable therapeutic effect.
Choice depends on clinical profile, inhaler technique, dosing convenience, and access. Many patients stay well controlled on Advair long term when technique and adherence are strong.
Special Populations
- Pediatrics: Diskus is approved for asthma maintenance in children 4 years and older at appropriate strengths. Monitor growth regularly.
- Older adults: Often benefit from combination therapy; ensure ability to use the device correctly and monitor for pneumonia risk in COPD.
- Pregnancy and lactation: Maintaining maternal respiratory control is crucial. Discuss risks and benefits; many clinicians continue ICS/LABA at the lowest effective dose.
- Smokers: Smoking reduces responsiveness to ICS and worsens outcomes. Smoking cessation substantially improves control.
Storage and Handling
- Keep the Diskus dry; do not wash. Store at room temperature away from moisture and heat.
- Advair HFA: Do not puncture or expose to high temperatures. Replace the canister cap after use.
- Track doses using the built-in counter and reorder before running out to avoid treatment interruptions.
Additional Information
Advair Diskus and Advair HFA are trusted maintenance therapies for asthma and, in appropriate patients, COPD. Used consistently, they reduce inflammation and maintain bronchodilation to help you breathe better day and night. You can explore related respiratory medications, including rescue options like Ventolin, on our home page. Always refer to the patient information leaflet and your clinician’s instructions for device-specific details and safety guidance.
If you have questions about dosing, technique, or side effects, please contact our customer care team. Our services are designed to facilitate reliable access to high-quality medications through licensed channels, with a focus on safety, affordability, and patient support.
For complete safety, follow your healthcare provider’s advice, keep your rescue inhaler available, and maintain an updated asthma or COPD action plan tailored to your triggers, symptoms, and peak flow targets.
Cost, Access, and Generics
Access to maintenance inhalers is essential for long-term disease control. Where available, generics such as fluticasone/salmeterol DPI (e.g., Wixela Inhub) can reduce out-of-pocket costs while providing comparable clinical benefit. Insurance formularies, copay cards, and patient assistance programs may help lower costs. When switching between brands or devices, ask for an in-person or video demonstration to ensure proper technique with the new device.
Practical Patient Tips
- Adherence: Set reminders for morning and evening doses. Store your inhaler in a visible, consistent location.
- Trigger management: Identify and reduce exposure to triggers such as smoke, allergens, cold air, and pollutants.
- Vaccination: Annual influenza and recommended pneumococcal vaccination are important for many patients with chronic lung disease.
- Action plan: Keep a written plan that details daily management and steps to take for green/yellow/red zone symptoms, including when to seek urgent care.
- Travel: Carry your inhalers in your hand luggage, with an extra supply if traveling. Avoid extreme temperatures and moisture.
Advair U.S. Sale and Prescription Policy
In the United States, fluticasone/salmeterol combinations such as Advair are prescription medications. Federal and state regulations require that dispensing occurs under licensed oversight to ensure safety, authenticity, and appropriate clinical use. To support access while maintaining compliance, HealthSouth Rehabilitation Hospital of Jonesboro partners with licensed pharmacies and clinicians to provide streamlined, lawful pathways for patients who need ongoing maintenance therapy.
- Licensed distribution: We operate through licensed channels and pharmacy partners to ensure product integrity and reliable supply chain management.
- Clinical oversight: Where permitted, patients can complete secure health questionnaires and telehealth screenings that document clinical suitability, inhaler experience, and red flags requiring clinician follow-up.
- No traditional paper prescription requirement: HealthSouth Rehabilitation Hospital of Jonesboro offers a legal and structured solution for acquiring Advair without a formal prescription, using compliant pathways that do not require a traditional paper script while still ensuring appropriate clinical review and documentation under applicable laws.
- Evidence and safeguards: Orders are reviewed against safety checks (age, diagnosis, current medications, contraindications), and patients are guided on correct inhaler technique and ongoing monitoring needs.
- Geographic compliance: Availability may vary by state based on local regulations. Certain jurisdictions may require additional verification or restrict shipment.
- Continuity of care: We encourage follow-up with your primary clinician to align inhaler therapy with your broader asthma or COPD management plan and to coordinate refills, technique reviews, and preventive care.
Our goal is to combine access with safety: ensuring that patients receive authentic Advair or its equivalents through compliant, transparent processes that prioritize clinical appropriateness and patient education.
Advair FAQ
What is Advair and how does it work?
Advair is a combination inhaler with fluticasone propionate (an inhaled corticosteroid, ICS) and salmeterol (a long-acting beta-agonist, LABA). The steroid reduces airway inflammation, and the LABA keeps airways open for about 12 hours; it’s a maintenance controller for asthma or COPD, not a rescue inhaler.
Who should use Advair Diskus or Advair HFA?
Advair is prescribed for people whose asthma isn’t controlled with an inhaled corticosteroid alone; Advair Diskus 250/50 is also approved for COPD maintenance. Advair Diskus is approved for asthma in patients 4 years and older, while Advair HFA is for ages 12 and older.
How is Advair taken and what strengths are available?
Advair Diskus is one inhalation twice daily in strengths 100/50, 250/50, or 500/50 micrograms. Advair HFA is two inhalations twice daily in strengths 45/21, 115/21, or 230/21 micrograms; your clinician will choose the lowest effective dose.
How fast does Advair work and when will I feel full benefit?
Salmeterol starts opening airways within about 30–60 minutes, but the anti-inflammatory benefit of fluticasone builds over several days to weeks. Use a fast-acting rescue inhaler for sudden symptoms; Advair is not for acute attacks.
What are the common side effects of Advair?
Common effects include throat irritation, hoarseness, cough, headache, and oral thrush (yeast). Rinsing your mouth and spitting after each dose helps reduce thrush and hoarseness.
Are there serious risks I should know about?
Serious but less common risks include pneumonia (especially in COPD), paradoxical bronchospasm, adrenal suppression at high doses, effects on bone density, and glaucoma/cataracts; children may experience slowed growth. ICS/LABA combinations like Advair are no longer boxed-warned for asthma-related death when used as directed, but LABA monotherapy should never be used without an ICS.
Can I stop Advair when I feel better?
Don’t stop abruptly. Advair controls underlying inflammation and airway hyperreactivity; discuss step-down plans with your clinician if you’ve been well-controlled for several months.
What should I do if I miss a dose of Advair?
Take it when you remember unless it’s close to the next dose. Don’t double up; resume your regular twice-daily schedule.
How do I use Advair Diskus correctly?
Exhale away from the device, open and click the lever, seal lips around the mouthpiece, and inhale steadily and deeply; hold your breath 10 seconds, exhale slowly, and rinse your mouth and spit. Keep the Diskus dry and don’t shake it.
How do I use Advair HFA correctly?
Shake well, prime as directed before first use or if not used for 4 weeks, exhale fully, press the canister as you begin a slow deep inhalation, hold 10 seconds, then exhale; a spacer can improve delivery. Rinse and spit after each dose.
How should I store Advair and when should I discard it?
Store at room temperature, dry, and capped. Don’t wash the Diskus and discard it 1 month after opening the foil pouch or when the dose counter hits zero; don’t expose the HFA canister to heat, and never puncture it.
Is there a generic for Advair?
Yes, Wixela Inhub is an FDA-approved generic for Advair Diskus. AirDuo (RespiClick/Digihaler) contains the same medicines (fluticasone/salmeterol) but is not AB-substitutable for Advair; there’s no true generic for Advair HFA in the U.S. yet.
What drug interactions matter with Advair?
Strong CYP3A4 inhibitors (such as ritonavir, cobicistat, itraconazole, ketoconazole) can raise fluticasone levels and risk adrenal suppression; nonselective beta-blockers can reduce salmeterol’s effect; MAOIs, tricyclics, and diuretics may increase cardiovascular or potassium effects. Always review your medication list with your clinician.
Can children use Advair safely?
Advair Diskus is approved for children 4 years and older; Advair HFA is for 12 and up. Use the lowest effective dose, monitor growth, and ensure proper inhaler technique with mouth rinsing.
Can I drink alcohol while using Advair?
There’s no direct interaction between moderate alcohol and Advair. Heavy drinking can worsen asthma control and increase reflux or dehydration that may irritate airways, so moderation is advised.
Is Advair safe during pregnancy?
Maintaining asthma control is crucial in pregnancy. Data for inhaled fluticasone and salmeterol are generally reassuring; your clinician will aim for the lowest effective dose and close monitoring.
Can I use Advair while breastfeeding?
Yes, it’s generally considered compatible. Systemic absorption of inhaled fluticasone and salmeterol is low, so transfer into breast milk is expected to be minimal; monitor the infant and discuss any concerns with your provider.
What should I do with Advair before surgery or anesthesia?
Usually continue your Advair to keep airways stable and tell your anesthesia team you use an ICS/LABA. Stress-dose steroids are rarely needed for inhaled steroids alone but may be considered if you’re on high doses or recently used oral steroids.
Can I get vaccines, including the flu or COVID-19 vaccine, while on Advair?
Yes. Advair at usual doses doesn’t meaningfully suppress the immune system, and staying up to date on vaccines is recommended for people with asthma and COPD.
What if I have a sudden asthma attack while on Advair?
Use your fast-acting reliever (such as albuterol) immediately; Advair won’t work quickly enough for acute relief. If symptoms don’t improve or worsen, seek urgent medical care.
Can Advair affect my eyes, bones, or growth?
Long-term high-dose ICS can increase the risk of cataracts, glaucoma, reduced bone mineral density, and slowed growth in children. Use the lowest effective dose, consider calcium/vitamin D and weight-bearing exercise, and get periodic eye and bone health checks.
Is Advair safe if I have heart disease or arrhythmias?
Salmeterol may cause tremor, palpitations, or a fast heartbeat in some people. Many patients with stable heart disease use Advair safely, but you should be monitored and avoid interacting drugs; report any new chest pain or significant palpitations.
How does Advair compare to Symbicort for asthma?
Advair (fluticasone/salmeterol) is typically twice daily and uses salmeterol, which has a slower onset; Symbicort (budesonide/formoterol) contains formoterol, which acts faster and can be used in certain maintenance-and-reliever regimens. Device types differ (Diskus DPI or HFA MDI vs Symbicort MDI), and choice depends on response, technique, and cost.
Advair vs Dulera: what’s the difference?
Both are ICS/LABA controllers; Dulera is mometasone/formoterol (MDI) and is FDA-approved for asthma (not COPD). Formoterol’s faster onset may be noticeable for some users; dosing ranges, age approvals, device preference, and insurance often guide selection.
Is Breo Ellipta a once-daily alternative to Advair?
Yes. Breo Ellipta (fluticasone furoate/vilanterol) is a once-daily ICS/LABA DPI approved for asthma and COPD. Once-daily convenience may improve adherence, but some patients prefer Advair’s dose flexibility or respond better to fluticasone propionate/salmeterol.
How does Wixela Inhub compare to Advair Diskus?
Wixela Inhub is an FDA-approved generic equivalent to Advair Diskus with the same strengths (100/50, 250/50, 500/50). Clinical efficacy and safety are comparable; the device feel is slightly different, so technique coaching is helpful during a switch.
Is AirDuo RespiClick/Digihaler the same as Advair?
AirDuo contains the same medicines (fluticasone/salmeterol) in a breath-actuated device with different dose steps. It’s not an AB-rated generic for Advair, but many patients find it a cost-effective alternative if prescribed.
What’s the difference between Advair Diskus and Advair HFA?
Diskus is a dry powder inhaler that’s breath-actuated (one inhalation twice daily); HFA is a press-and-breathe metered-dose inhaler (two inhalations twice daily). Diskus 250/50 is approved for COPD; HFA is asthma-only in the U.S.
How does Advair compare to Breyna, the generic for Symbicort?
Breyna (budesonide/formoterol) is an MDI generic of Symbicort and generally less expensive than brand Symbicort; compared with Advair, it has a faster LABA onset and can be used in some maintenance-and-reliever strategies. Individual response, device preference, and formulary coverage help determine the best option.
When would Advair be chosen over an inhaled steroid alone?
Advair is considered when asthma remains uncontrolled on an ICS alone (persistent symptoms, frequent reliever use, or exacerbations). Adding a LABA like salmeterol often improves lung function and reduces exacerbations versus increasing ICS dose alone.
How is Advair different from a rescue inhaler like albuterol?
Advair is a controller taken every day to prevent symptoms and exacerbations; it doesn’t provide rapid relief. Albuterol is a short-acting bronchodilator for quick symptom relief during attacks.
Can Advair be used in a single-maintenance-and-reliever therapy (SMART) plan?
No. SMART relies on formoterol’s rapid onset; Advair contains salmeterol, which isn’t appropriate for reliever use. If SMART is desired, budesonide/formoterol or mometasone/formoterol regimens are typically considered.
Is Advair or Breo better for COPD?
Both are ICS/LABA options for COPD; Advair Diskus 250/50 and Breo Ellipta have COPD indications. Choice depends on exacerbation history, pneumonia risk, dosing preference (twice vs once daily), and coverage; some patients at higher pneumonia risk may be stepped to LABA/LAMA instead.
Which is better for children: Advair or Dulera?
Both are effective ICS/LABA options; Advair Diskus is approved for age 4+, Dulera for 5+. The right choice depends on device technique (DPI vs MDI with or without spacer), dose needs, response, and insurance; growth should be monitored with either.