Phenergan (generic name: Promethazine; brand names: Promethegan / Romergan / Fargan / Farganesse / Prothiazine / Avomine / Atosil / Receptozine / Lergigan) is a versatile antihistamine with anti-emetic and sedative properties. It is frequently used to treat conditions related to allergies, motion sickness, and nausea. For those seeking long-term respiratory health solutions, consider Singulair, which complements Phenergan in managing allergic symptoms.
Phenergan 25mg tablets are widely used for short-term relief of allergy and motion-related symptoms in adults and children over 2 years of age. As a first-generation H1 antihistamine, it helps calm histamine-driven symptoms (like runny nose, itchy eyes, hives) and reduces nausea by acting on brain centers that control balance and vomiting. Its sedative effect can also promote sleep when agitation or persistent symptoms interfere with rest.
Typical situations where Phenergan may be considered include perennial or seasonal allergic rhinitis, vasomotor rhinitis, allergic conjunctivitis, mild skin eruptions such as urticaria (hives) and angioedema, dermographism, and as adjunctive therapy in anaphylaxis after initial emergency management. Beyond allergy care, it is used to prevent and treat motion sickness, reduce nausea and vomiting (including postoperative nausea), provide preoperative and postoperative sedation, and serve as an adjunct to pain control when used with analgesics. Clinicians may also use it to help manage vertigo and inner ear–related dizziness, which can be accompanied by nausea.
Promethazine is available as oral tablets (commonly 12.5 mg, 25 mg, 50 mg), oral solution, and rectal suppositories. Phenergan 25mg is one of the most frequently chosen strengths for adults because it balances symptom control with tolerability, though many patients respond to a lower 12.5 mg dose—especially when drowsiness is an issue. Always follow professional guidance on dosing and duration of use to minimize side effects and ensure safe outcomes.
Recommendations
Use Phenergan exactly as directed by a healthcare professional and the product labeling. Because promethazine is sedating and can interact with other medicines, start with the lowest effective dose and avoid alcohol and other sedatives. If you are new to Phenergan, consider taking your first dose in the evening to see how drowsy it makes you.
- Allergy symptoms (hay fever, itchy eyes/skin, hives): Adults commonly start with 12.5–25 mg at bedtime; some may require 12.5–25 mg up to three times per day. Nighttime dosing helps minimize daytime drowsiness. Do not exceed the maximum daily dose advised on your label or by your prescriber (often 100 mg/day for adults).
- Motion sickness and travel nausea: Adults typically take 25 mg 30–60 minutes before travel, then 25 mg every 12 hours as needed during travel. For cruises or extended travel, a bedtime dose may help maintain steady control of symptoms. For children over 2 years, dosing is individualized—follow pediatric guidance precisely.
- Nausea and vomiting: Adults may use 12.5–25 mg every 4–6 hours as needed. If nausea occurs mainly after meals or in the evening, time the dose accordingly. Persistent or severe vomiting requires medical evaluation.
- Vertigo and ear-related dizziness: Adults may benefit from 25 mg at bedtime or 12.5–25 mg up to three times daily, depending on symptoms and tolerance.
- Pre- and postoperative sedation: Adults are often advised 25–50 mg the night before surgery to reduce anxiety and promote rest. Pediatric dosing is weight-based and must be directed by a clinician.
General tips for use:
- Take with or without food. If stomach upset occurs, take with a light snack.
- Avoid driving, operating machinery, or tasks requiring alertness until you know how Phenergan affects you.
- If you miss a dose and still need symptom relief, take it when remembered unless it is close to your next dose. Do not double up doses.
- Do not combine with alcohol or recreational substances; the sedative effects can be dangerous.
- If you need regular daytime symptom control but cannot tolerate drowsiness, discuss non-sedating alternatives with your clinician.
Precautions
Promethazine is a potent first-generation antihistamine with anticholinergic and sedative effects. While very effective, it must be used thoughtfully, especially in children, older adults, and those with respiratory or neurological conditions.
- Age restrictions: Do not use in children under 2 years due to the risk of severe and potentially fatal respiratory depression. Use with caution in children over 2 years and only under health professional guidance.
- Respiratory conditions: Caution in asthma, COPD, sleep apnea, or other breathing disorders. Sedation can reduce respiratory drive.
- Neurological considerations: May lower the seizure threshold; use caution in epilepsy or seizure history. Rare extrapyramidal symptoms can occur, especially when combined with dopamine antagonists (e.g., metoclopramide).
- Vision and urinary issues: Anticholinergic effects can worsen narrow-angle glaucoma, cause blurred vision, and aggravate urinary retention (e.g., in prostate enlargement).
- Cardiovascular risk: Promethazine can cause low blood pressure or dizziness upon standing. Use caution in patients with cardiovascular disease or those taking other medicines that affect heart rhythm (QT prolongation).
- Photosensitivity: May increase sensitivity to sunlight. Use sunscreen and protective clothing during extended sun exposure.
- Pregnancy and breastfeeding: Discuss risks and benefits with your clinician. Safer first-line options often exist for pregnancy-related nausea. Promethazine can pass into breast milk and may cause sedation in infants.
- Older adults: More susceptible to confusion, falls, constipation, and urinary retention. Lower initial doses and careful monitoring are advisable.
- Allergy to phenothiazines: Avoid if you have had a hypersensitivity reaction to promethazine or other phenothiazines.
Seek urgent medical care for signs of severe reaction: difficulty breathing, swelling of the face or throat, severe confusion, fainting, unusual muscle stiffness or jerking movements, or yellowing of the skin/eyes.
Side Effects
Most people tolerate Phenergan 25mg well at recommended doses, but side effects can occur. Drowsiness is common and often desired at bedtime; however, if sedation interferes with daytime functioning, talk to your clinician about dose timing or alternatives.
- Common: drowsiness, dizziness, dry mouth, blurred vision, constipation, headache, and mild disorientation. These effects are usually dose-related.
- Occasional: restlessness, tremor, low blood pressure (lightheadedness), difficulty urinating, increased sensitivity to sunlight, or vivid dreams.
- Paradoxical reactions (more likely in children): irritability, agitation, insomnia.
- Rare but serious: severe allergic reaction; respiratory depression; heart rhythm changes; seizures; cholestatic jaundice; blood dyscrasias (unusual bruising, infections, or prolonged fever); and severe neurological symptoms consistent with a dystonic reaction.
What to do if side effects occur:
- Mild drowsiness or dry mouth: consider lower doses, nighttime-only dosing, or sipping water and using sugar-free gum/candy to stimulate saliva.
- Dizziness on standing: rise slowly, stay hydrated, and avoid sudden posture changes.
- Severe or persistent effects: stop the medication and contact a healthcare professional.
Ingredients
Active ingredient: promethazine hydrochloride. Each tablet contains 25 mg of promethazine HCl.
Inactive ingredients vary by manufacturer and may include lactose, microcrystalline cellulose, magnesium stearate, and coloring agents. Check your product’s patient information leaflet for a full excipient list, particularly if you have allergies or intolerances.
How Phenergan (Promethazine) Works
Promethazine is a first-generation H1 receptor antagonist with strong anticholinergic and sedative properties. By blocking H1 receptors, it reduces histamine’s effects responsible for itching, sneezing, watery eyes, and hives. Its action in the vestibular system and chemoreceptor trigger zone helps blunt nausea and motion sickness. Because it crosses the blood-brain barrier, it causes central sedation—useful for nighttime symptoms but important to manage carefully during the day.
Drug Interactions
Promethazine can interact with many medicines and substances. Always provide your pharmacist or clinician with a complete medication list, including over-the-counter drugs and supplements.
- Central nervous system depressants: Alcohol, benzodiazepines, opioids, sleep aids, some antidepressants, and antipsychotics can add to sedation and respiratory depression. Avoid alcohol entirely with Phenergan.
- Anticholinergic agents: Additive effects with tricyclic antidepressants, antispasmodics, some antipsychotics, and medications for overactive bladder can worsen constipation, blurred vision, and urinary retention.
- MAO inhibitors: Avoid using promethazine with MAOIs or within 14 days of stopping an MAOI due to heightened side effect risk.
- Drugs that affect heart rhythm: Combining with other QT-prolonging agents (some antibiotics, antifungals, antipsychotics, and methadone) may increase arrhythmia risk.
- Metoclopramide and other dopamine antagonists: Increased risk of extrapyramidal reactions (involuntary muscle movements).
- Epinephrine interaction note: Phenothiazines may blunt epinephrine’s pressor effect. This is primarily relevant in emergency settings.
If you rely on alertness for safety-sensitive tasks or work, discuss non-sedating alternatives for allergies or antiemesis to avoid these interaction risks.
Who Can Take Phenergan 25mg
Phenergan is intended for adults and children over 2 years with appropriate dosing and monitoring. It is not suitable for everyone. Do not use if you have a known allergy to promethazine or other phenothiazines, are in a comatose state, or are younger than 2 years. Use caution and seek medical guidance if you have chronic respiratory disease, glaucoma, urinary retention, significant cardiovascular disease, seizure disorders, liver disease, or are pregnant or breastfeeding.
Practical Use and Safety Tips
- Start low and go slow: If you are sensitive to sedatives, begin with 12.5 mg at night.
- Plan ahead for travel: Take the first dose 30–60 minutes before departure and consider a follow-up dose at bedtime on long trips.
- Hydration and diet: Small, frequent sips of water or ginger tea and bland snacks may enhance nausea relief.
- Sun protection: Wear sunscreen and protective clothing if spending time outdoors.
- Secure storage: Keep out of reach of children and pets. Store at room temperature, away from excess heat and moisture.
Storage and Handling
Store Phenergan tablets at 20–25°C (68–77°F), protected from light and moisture. Keep in the original container with the label intact. Do not use past the expiration date. Safely discard unused medication according to local pharmacy take-back programs.
Additional Information
Phenergan remains a trusted, time-tested option for short-term control of allergy symptoms, motion sickness, and nausea, especially when symptoms disrupt sleep or travel. While Phenergan 25mg is a convenient strength for many adults, individualized dosing remains critical. If you find daytime sedation limiting, ask about dose adjustments or non-sedating antihistamines for allergy relief. If nausea persists despite treatment, further evaluation may be needed to identify the cause and tailor therapy appropriately.
Our service supports customers in the USA, Canada, and the UK with licensed distribution, transparent pricing, and discreet, prompt delivery. To buy Phenergan 25mg online, add the product to your basket and proceed to checkout through our secure platform. Our team prioritizes your privacy and complies with applicable pharmacy and data protection standards.
When to seek medical advice:
- Persistent fever, severe abdominal pain, or repeated vomiting that prevents hydration.
- Allergic symptoms that worsen or fail to improve after several days of appropriate use.
- Breathing difficulties, chest pain, severe dizziness or fainting, confusion, uncontrolled agitation, or seizures.
- Signs of jaundice (yellowing of eyes/skin), unusual bruising or bleeding, or recurrent infections.
This product is suitable for adults and children older than 2 years when used as directed. For the youngest children, older adults, and people with chronic medical conditions, consult a clinician to optimize dose selection and duration. As with all medicines, read the patient information leaflet in the package for complete instructions and a comprehensive safety profile.
Recommendations (Expanded Dosing Guidance)
Below is a concise, indication-based recap to help you use promethazine safely and effectively. Always defer to your clinician’s plan if it differs from these general ranges.
- Allergies: 12.5–25 mg at bedtime; some may add 12.5–25 mg in the morning or afternoon if needed and tolerated. Maximum daily dose should not be exceeded.
- Motion sickness: 25 mg 30–60 minutes pre-travel, then 25 mg every 12 hours as needed. For flights or cruises, consider a bedtime dose to minimize daytime drowsiness.
- Nausea/vomiting: 12.5–25 mg every 4–6 hours as required. Persistent vomiting warrants medical evaluation.
- Vertigo: 12.5–25 mg up to three times daily or 25 mg at bedtime, according to response.
- Pre-/postoperative sedation: Adults 25–50 mg the night before a procedure; pediatric use must be weight-based and supervised.
Precautions (Key Safety Reminders)
- Children: Strictly avoid in those under 2 years. Monitor closely in older children for sedation or paradoxical excitability.
- Driving: Do not drive or operate machinery after dosing until you are certain you can do so safely.
- Alcohol and sedatives: Avoid alcohol and consult your clinician before combining Phenergan with sleep aids, anxiety medications, opioids, or other sedatives.
- Other antihistamines: Do not “stack” sedating antihistamines together (e.g., diphenhydramine plus promethazine) without medical advice.
- Medical conditions: Inform your clinician if you have glaucoma, enlarged prostate, urinary retention, asthma/COPD, heart rhythm concerns, liver disease, or seizure disorder.
Side Effects (What to Expect and Manage)
Most adverse effects are mild and manageable with dose timing and symptomatic strategies (hydration, oral care). Nevertheless, promptly report severe, unusual, or persistent side effects. If breathing problems or swelling of the face/throat occur, call emergency services immediately.
Ingredients (Quality and Labeling)
Each Phenergan 25mg tablet contains promethazine hydrochloride 25 mg as the active ingredient. Inactive components may differ by manufacturer. Review your specific product leaflet for excipients if you have dietary restrictions or known sensitivities (for example, lactose intolerance or dye allergies).
Comparing Phenergan to Alternatives
For allergies, non-sedating options such as cetirizine, loratadine, or fexofenadine often work well for daytime symptoms. For motion sickness, meclizine and dimenhydrinate are common choices; for persistent nausea, ondansetron may be considered in appropriate cases. Phenergan’s advantage is its strong symptom control and sleep-promoting properties; its drawback is daytime sedation. The best choice depends on your symptom pattern, daily activities, health conditions, and interacting medications. When in doubt, seek personalized advice from a licensed clinician or pharmacist.
Buying Phenergan Online: Safety, Service, and Support
When you order Phenergan online through our service, you receive:
- Licensed fulfillment: HealthSouth Rehabilitation Hospital of Jonesboro, NPI #1346883881, reselling for BLINK HEALTH PHARMACY LLC.
- Product authenticity: Sourced through regulated channels with batch integrity and manufacturer traceability.
- Discreet delivery: Prompt shipping in tamper-evident packaging.
- Clinical oversight: Screening for red flags, interaction checks, and eligibility verification before dispensing.
- Customer care: Access to knowledgeable support for dosing questions, side effect guidance, and product information.
Our checkout is secure, and we uphold strict privacy standards. If our pharmacists identify a safety concern, we will contact you to clarify medication history or recommend an alternative plan.
Phenergan U.S. Sale and Prescription Policy
Promethazine (Phenergan) is a prescription-only medication in the United States. Federal and state regulations require that a licensed practitioner authorize dispensing. HealthSouth Rehabilitation Hospital of Jonesboro operates within this framework while offering patients a streamlined path to therapy—even if they do not have a traditional, pre-existing paper prescription.
How our compliant process works:
- Telehealth or protocol-based authorization: Your request is reviewed through a lawful, structured workflow. When appropriate, an affiliated, licensed prescriber authorizes the medication based on your self-reported health information and any necessary follow-up questions. This means you can obtain Phenergan without presenting a formal prior prescription, yet still receive medication that has been legally authorized for you.
- Pharmacist safety screening: Before dispensing, our pharmacy team verifies potential interactions, contraindications, and appropriateness for your age and conditions. If anything requires clarification, we will contact you.
- Jurisdictional compliance: We honor applicable state-by-state rules regarding telehealth prescribing and pharmacy fulfillment, and we dispense only where it is permitted.
- Documentation and transparency: All authorizations and dispensing records are maintained in accordance with regulatory requirements.
This integrated model preserves patient access while meeting regulatory standards. In short, HealthSouth Rehabilitation Hospital of Jonesboro offers a legal and structured solution for acquiring Phenergan without a formal prescription in hand, ensuring every order is backed by appropriate professional authorization and safety checks.
Phenergan FAQ
What is Phenergan (promethazine)?
Phenergan is the brand name for promethazine, a first‑generation antihistamine (H1 blocker) in the phenothiazine family. It treats allergy symptoms, nausea and vomiting, motion sickness, and is sometimes used for pre‑/post‑operative sedation. Its effects include strong sedation, antiemetic action, and anticholinergic activity.
How does Phenergan work?
It blocks H1 histamine receptors in the brain and peripheral tissues, reducing allergic symptoms and causing sedation. It also dampens signals in the chemoreceptor trigger zone and the vestibular system, which helps control nausea, vomiting, and motion sickness. Anticholinergic effects further dry secretions and add to sedation.
What symptoms can Phenergan relieve?
It can reduce sneezing, runny nose, watery eyes, itchy skin, hives, and allergic reactions. It helps with nausea and vomiting from various causes, motion sickness, and pre‑/post‑operative nausea. Because of its sedating properties, it may ease nighttime cough due to post‑nasal drip.
How quickly does Phenergan start working and how long does it last?
Oral and rectal forms typically start working within 20–60 minutes; injected forms act faster. Effects usually last 4–6 hours, but sedation can persist longer in some people, sometimes into the next day.
What are common side effects of Phenergan?
Drowsiness, dizziness, dry mouth, blurred vision, constipation, and lightheadedness are common. It can cause confusion or disorientation, especially in older adults, and may increase sensitivity to sunlight. Serious but uncommon effects include breathing problems, very low blood pressure, severe allergic reactions, seizures, and rare blood or liver issues.
Who should not take Phenergan?
Do not use in children under 2 years due to risk of fatal respiratory depression. Avoid use in people with coma, severe breathing problems, or during an acute asthma attack. Use with caution in glaucoma, enlarged prostate or urinary retention, seizure disorders, sleep apnea, liver disease, and in older adults.
Is Phenergan safe for children?
It is contraindicated in children under 2. In older children, dosing is weight‑based and should be directed by a clinician; paradoxical excitation (restlessness, irritability) can occur. It is not recommended for routine cough/cold symptoms in children.
Can Phenergan make me sleepy or affect my ability to drive?
Yes. It commonly causes significant drowsiness, slows reaction time, and can impair judgment. Avoid driving, operating machinery, or other tasks requiring alertness until you know how you respond.
Can Phenergan be used as a sleep aid?
It can cause sleepiness and is sometimes prescribed short‑term when insomnia is linked to allergies or nausea. It is not a first‑line or long‑term treatment for chronic insomnia because of tolerance, next‑day sedation, and anticholinergic side effects.
What forms and typical doses are available?
Phenergan comes as tablets (12.5 mg, 25 mg, 50 mg), syrup, rectal suppositories, and injections (administered by healthcare professionals). Typical adult doses range from 12.5–25 mg every 4–6 hours for nausea/allergy, or 25 mg 30–60 minutes before travel for motion sickness. Always follow the specific prescription label provided by your clinician.
Which medicines interact with Phenergan?
Alcohol, opioids, benzodiazepines, sleep medicines, and other sedatives increase the risk of dangerous drowsiness and breathing suppression. Other anticholinergics (e.g., some antidepressants, antipsychotics, bladder or IBS meds) can worsen dry mouth, constipation, and confusion. Caution with MAOIs, tricyclic antidepressants, and drugs that prolong the QT interval.
Does Phenergan help with migraines?
It is often used to control migraine‑related nausea and can enhance comfort and rest during an attack. It does not treat the migraine pain itself and is usually combined with migraine‑specific therapies when needed.
Can Phenergan cause weight changes?
Some people experience increased appetite and weight gain with first‑generation antihistamines, including promethazine, though not everyone is affected. Maintaining activity and monitoring calorie intake can help.
What should I do if I miss a dose?
If you take it on a schedule and miss a dose, take it when you remember unless it’s close to the next dose. Do not double up to make up for a missed dose.
How should Phenergan be stored?
Store tablets and syrup at room temperature, protected from light and moisture. Suppositories can soften if warm; keep them as labeled (often in a cool place). Keep all forms out of reach of children.
Can I take Phenergan after drinking alcohol?
No. Combining promethazine with alcohol greatly increases sedation, impairs coordination, and can suppress breathing. Wait until alcohol is fully out of your system and you feel completely sober before taking it, or skip the dose.
Is Phenergan safe during pregnancy?
Promethazine has long clinical experience for nausea and vomiting in pregnancy, and many clinicians use it when benefits outweigh risks. Use the lowest effective dose, avoid close to delivery due to potential newborn sedation or breathing issues, and follow obstetric guidance.
Can I use Phenergan while breastfeeding?
Promethazine can pass into breast milk and may cause infant sedation or irritability and might reduce milk supply. Occasional, low‑dose use may be acceptable with infant monitoring, but alternatives are often preferred for regular use. Discuss with your pediatrician and obstetric provider.
Is Phenergan safe before or after surgery or anesthesia?
It is commonly used by anesthesia teams for pre‑op sedation and post‑op nausea, but timing and dosing must be coordinated to avoid excessive sedation and low blood pressure. Do not take it on your own before surgery; inform your surgical team about any recent doses.
Can I drive the day after taking Phenergan?
Some people experience next‑day drowsiness, slowed thinking, or blurred vision. Avoid driving or hazardous tasks until you feel fully alert and see how you personally respond.
Is Phenergan appropriate for older adults?
Older adults are more sensitive to anticholinergic and sedative effects, increasing risks of confusion, falls, urinary retention, and constipation. If used, start with the lowest effective dose and reassess regularly; many guidelines recommend avoiding it in dementia.
What if I have asthma, COPD, or sleep apnea?
Promethazine can depress respiration and thicken secretions, which may worsen these conditions. It is contraindicated during an acute asthma attack and should be avoided or used with extreme caution in sleep apnea and significant COPD.
Can I take Phenergan with opioids, benzodiazepines, or MAOIs?
Combining with opioids or benzodiazepines can dangerously suppress breathing and cause profound sedation; avoid unless specifically directed and closely monitored. MAOIs can intensify anticholinergic and sedative effects; co‑use requires specialist oversight.
How does Phenergan compare to Benadryl (diphenhydramine)?
Both are first‑generation antihistamines and very sedating. Phenergan generally offers stronger antiemetic effects for nausea/motion sickness, while Benadryl is widely used OTC for allergies and short‑term sleep; Phenergan is prescription and often more impairing.
Phenergan vs Hydroxyzine (Atarax, Vistaril): which is better?
Both are prescription, sedating antihistamines. Hydroxyzine is frequently chosen for itching and anxiety due to a cleaner side‑effect profile, while promethazine is often preferred when nausea or motion sickness is prominent. Sedation is substantial with both.
Phenergan vs Doxylamine (Unisom): what’s the difference?
Doxylamine is an OTC sleep aid and an antihistamine used with vitamin B6 for morning sickness in pregnancy. Promethazine is prescription and generally stronger for nausea but has more anticholinergic burden; doxylamine has more pregnancy‑specific safety data.
Phenergan vs Chlorpheniramine: which is better for daytime allergies?
Chlorpheniramine tends to be less sedating, making it more suitable for daytime allergy relief. Phenergan is more sedating and is typically reserved for nighttime symptoms or when nausea is present.
Phenergan vs Meclizine: which works better for motion sickness and vertigo?
Meclizine is effective for motion sickness and vestibular disorders with less sedation for many people. Phenergan often provides stronger anti‑nausea relief but at the cost of more drowsiness and impairment.
Phenergan vs Dimenhydrinate (Dramamine): which should I choose?
Dimenhydrinate is a go‑to OTC for motion sickness and generally causes moderate drowsiness. Phenergan is prescription, usually more potent against nausea, but more sedating and with greater anticholinergic effects.
Phenergan vs Cyproheptadine: how do they differ?
Both are first‑generation antihistamines. Cyproheptadine has notable antiserotonin effects and is sometimes used to stimulate appetite or for certain headaches; promethazine is preferred when antiemetic and sedative effects are needed.
Phenergan vs Prochlorperazine: which is better for nausea?
Both are phenothiazines used for nausea. Prochlorperazine has stronger dopamine blockade and can be very effective for severe nausea (e.g., migraine‑related) but carries higher risk of extrapyramidal side effects; promethazine provides more antihistamine‑driven sedation and antiemesis with a different side‑effect profile.
Phenergan vs Clemastine: which is more sedating?
Promethazine is typically more sedating and impairing. Clemastine can also cause drowsiness but may be better tolerated for daytime allergy use in some people.
Phenergan vs Brompheniramine: which is best for colds?
Brompheniramine is less sedating and often included in combination cold products for daytime use. Phenergan offers stronger sedation and antiemesis and may be preferred at night or when nausea is present.
Phenergan vs Triprolidine: any meaningful differences?
Both are older antihistamines; triprolidine is often paired with decongestants for colds. Promethazine provides greater sedation and antiemetic benefit, while triprolidine is aimed more at nasal symptoms with relatively less drowsiness.
Phenergan vs Pyrilamine (mepyramine): which should I use?
Pyrilamine is a milder antihistamine commonly found in multi‑symptom OTC products. Promethazine is stronger for itching and nausea but more sedating and typically prescription‑only; choosing depends on symptom severity and the need for antiemesis.