
Serevent (salmeterol) is a long-acting beta2-adrenergic agonist (LABA) inhaler designed for maintenance control of bronchospasm. It is available as a dry powder inhalation device (often supplied as Serevent Diskus) and delivers a long-lasting bronchodilator effect to help keep airways open over a 12-hour period.
This medicine is used for long-term, twice-daily maintenance treatment of asthma and chronic obstructive pulmonary disease (COPD), and for prevention of exercise-induced bronchospasm (EIB). Importantly, in asthma, salmeterol should not be used as monotherapy; it must be paired with an inhaled corticosteroid (ICS) to reduce the risk of asthma-related complications. It is not a rescue inhaler and does not treat sudden breathing symptoms.
What Serevent (salmeterol) does and does not do
Salmeterol selectively stimulates beta2 receptors in airway smooth muscle, causing bronchodilation that begins within minutes, peaks over a few hours, and lasts about 12 hours. By keeping bronchial muscles relaxed, it reduces day-to-day symptoms like wheeze and chest tightness and lowers the risk of nighttime awakenings.
- What it does: Provides maintenance bronchodilation; reduces symptom burden; prevents exercise-induced bronchospasm when taken before activity.
- What it does not do: It does not treat acute asthma attacks or sudden shortness of breath; a short-acting beta2-agonist (SABA) such as albuterol is required for immediate relief. It does not replace anti-inflammatory therapy (inhaled corticosteroids) in asthma.
Regulatory note: Single-ingredient LABAs like salmeterol carry a boxed warning regarding increased risk of asthma-related death when used without an inhaled corticosteroid. For most people with asthma, guidelines recommend an ICS or an ICS/LABA combination as foundational therapy.
Recommendations
Always use Serevent exactly as prescribed. Your clinician will tailor the dose to your diagnosis, symptom pattern, and response to treatment. Typical directions include:
- Asthma maintenance: One inhalation (50 micrograms) twice daily, morning and evening, about 12 hours apart. Use with a separate inhaled corticosteroid unless your regimen includes an ICS/LABA combination product.
- COPD maintenance: One inhalation (50 micrograms) twice daily, about 12 hours apart.
- Prevention of exercise-induced bronchospasm (EIB): One inhalation 30 to 60 minutes before exercise. Do not use additional doses if you are already taking Serevent twice daily; talk with your clinician about the best plan for EIB if you are on scheduled LABA therapy.
Key use tips:
- Do not use Serevent for acute symptoms; carry a rescue inhaler (for example, albuterol) for sudden wheeze or breathlessness.
- Use every day as directed, even when you feel well. Skipping doses reduces protection.
- If you miss a dose, take the next dose at the regular time. Do not double up.
- Do not exceed the recommended dosing frequency (no more than twice daily) as higher exposure increases side-effect risk without added benefit.
- In asthma, pair Serevent with an inhaled corticosteroid unless your clinician specifically advises otherwise. If you are stepped up to an ICS/LABA combination inhaler, your clinician may discontinue separate Serevent to avoid duplication.
When to seek help:
- If you need your rescue inhaler more than usual, wake up at night with breathing problems, or notice declining lung function, contact your clinician. Your treatment plan may need adjustment.
- If your symptoms acutely worsen, use your rescue inhaler and seek urgent medical care. Serevent is not for emergencies.
Precautions
Before using Serevent, discuss your full medical history and medication list with your healthcare provider. Important precautions include:
- Asthma safety: Do not use Serevent as monotherapy in asthma due to the risk of asthma-related complications. It should be used with an inhaled corticosteroid in most cases.
- Milk protein allergy: Serevent Diskus contains lactose, which may include trace milk proteins. Avoid if you have a severe milk protein allergy.
- Cardiovascular conditions: Use caution if you have arrhythmias, coronary artery disease, hypertension, long QT syndrome, or heart failure. Beta-agonists can increase heart rate and blood pressure and may precipitate arrhythmias in susceptible individuals.
- Endocrine/metabolic disorders: Use carefully in hyperthyroidism, diabetes mellitus (can transiently raise blood glucose), and in conditions predisposed to hypokalemia (for example, with certain diuretics); LABAs can lower serum potassium.
- Seizure disorders: Beta-agonists may rarely lower the seizure threshold.
- Pregnancy and breastfeeding: Discuss risks and benefits. Uncontrolled asthma or COPD poses significant risks to parent and fetus/infant. Salmeterol’s systemic exposure is low with inhaled use; many clinicians continue or initiate controller therapy to maintain maternal respiratory stability.
- Pediatric use: Approved for asthma and EIB in children 4 years and older when clinically indicated. Always pair with appropriate anti-inflammatory therapy in asthma.
- Not for acute deterioration: Do not initiate Serevent during rapidly worsening asthma or COPD. If disease acutely worsens on therapy, seek medical evaluation promptly.
Ingredients
Active ingredient: salmeterol xinafoate, delivering 50 micrograms of salmeterol base per inhalation.
Inactive ingredients: lactose (may contain milk proteins), which acts as the carrier for the dry powder. No propellant is used in the Diskus device.
How Serevent works: pharmacology and timing
Salmeterol binds selectively to beta2 receptors on airway smooth muscle. Its long side chain allows persistent receptor interaction, contributing to prolonged bronchodilation. After inhalation:
- Onset: Typically within 10 to 20 minutes.
- Peak effect: Often reached around 3 hours.
- Duration: Approximately 12 hours per dose, supporting twice-daily dosing.
Because there is a delay to peak effect, Serevent is unsuitable for rapid relief. Its strength lies in maintaining open airways between doses, stabilizing symptoms across day and night.
Proper inhaler technique and storage
Correct technique is essential to receive the right dose from a dry powder inhaler:
- Open the Diskus as instructed until you hear or feel a click.
- Slide the lever fully until it clicks to load a blister dose. Do not tilt, shake, or blow into the device.
- Breathe out fully away from the mouthpiece.
- Seal your lips around the mouthpiece and inhale quickly and deeply through your mouth to draw the powder into your lungs.
- Remove the inhaler and hold your breath for about 10 seconds or as long as comfortable, then exhale slowly.
- Close the Diskus. Do not take additional inhalations unless directed.
General tips:
- Do not wash the Diskus; keep it dry. Wipe the mouthpiece with a dry tissue if needed.
- Store at room temperature in a dry place away from moisture and heat. Keep the device closed when not in use.
- Monitor the dose counter and discard the device when the counter reads zero or after the recommended in-use period (often 6 weeks after opening, or per manufacturer’s instructions).
- If you also use an inhaled corticosteroid, use that inhaler as directed and rinse your mouth after steroid use to reduce the risk of oral thrush.
Side effects and adverse reactions
Most people tolerate Serevent well. Side effects, when they occur, are often dose-related and transient:
- Common: headache, throat irritation, hoarseness/dysphonia, cough, sinus irritation, dizziness, tremor, nervousness, palpitations, rapid heartbeat, muscle cramps.
- Metabolic: mild decreases in serum potassium; transient increases in blood glucose.
- Hypersensitivity: rare rash, urticaria, angioedema; avoid if you have a known severe milk protein allergy due to lactose content.
- Paradoxical bronchospasm: very rare but serious tightening of the airways after dosing; discontinue and seek immediate care if this occurs.
- Cardiac arrhythmias: risk increases in those with underlying heart conditions or with interacting drugs that prolong QT interval.
Asthma-related safety: In asthma, using a LABA without an inhaled corticosteroid increases the risk of severe exacerbations and death. Always follow your clinician’s plan to include anti-inflammatory therapy. Combination ICS/LABA products have not shown the same increased risk signal when used as directed.
Drug interactions
Tell your healthcare provider and pharmacist about all prescription, over-the-counter, and herbal products you use.
- Strong CYP3A4 inhibitors (for example, ketoconazole, itraconazole, ritonavir, cobicistat, clarithromycin) can increase salmeterol levels, raising the risk of adverse effects and QT prolongation. Avoid or monitor closely.
- Beta-blockers (nonselective more than cardioselective) may blunt the bronchodilator effect of salmeterol and trigger bronchospasm; use with caution or avoid in asthma/COPD unless necessary and carefully selected.
- Other sympathomimetics (decongestants, stimulants) can add to cardiovascular side effects; limit concurrent use.
- QT-prolonging agents (some antiarrhythmics, macrolides, antipsychotics) may increase arrhythmia risk when combined with LABAs.
- Diuretics that lower potassium (loop or thiazide diuretics) may potentiate hypokalemia; monitor if combined.
- Monoamine oxidase inhibitors (MAOIs) and tricyclic antidepressants can amplify sympathomimetic effects; use caution if administered within 2 weeks of such agents.
Who can use Serevent and who should avoid it
- Appropriate candidates: Adults and children 4 years and older who require maintenance bronchodilation for asthma or EIB prevention (with ICS support in asthma), and adults with COPD who benefit from twice-daily LABA therapy.
- Avoid or use with caution: Individuals with severe milk protein allergy; patients with unstable cardiac disease, uncontrolled hyperthyroidism, significant arrhythmias, or those on multiple QT-prolonging drugs without careful monitoring.
Not for acute rescue. If you are short of breath right now, use your prescribed rescue inhaler and seek emergent care as needed.
Serevent in asthma: positioning within controller therapy
Asthma management prioritizes airway inflammation control with inhaled corticosteroids. A LABA like salmeterol is added when symptoms persist despite low- or medium-dose ICS. Options include:
- Separate ICS plus Serevent: Some patients use distinct inhalers; adherence to both is critical.
- Fixed-dose ICS/LABA combinations: These pair an ICS with a LABA in one device, improving convenience and adherence. If you switch to a combination containing salmeterol (for example, one with fluticasone/salmeterol), your clinician will typically discontinue separate Serevent to avoid duplicating the LABA.
For people whose asthma is well controlled for 3 months or longer, clinicians may consider step-down strategies, potentially lowering the steroid dose. Discontinuing the LABA may be considered only when appropriate and under supervision, as abrupt changes can destabilize control.
Serevent in COPD: maintenance bronchodilation
In COPD, maintenance bronchodilation improves breathlessness, exercise tolerance, and quality of life. Serevent provides sustained bronchodilation as part of a long-term plan. Depending on symptoms and exacerbation history, your clinician may choose:
- LABA alone (such as salmeterol) in stable disease.
- LABA plus LAMA (long-acting muscarinic antagonist) dual bronchodilation for greater symptom control.
- Triple therapy (ICS/LABA/LAMA) if exacerbations persist in appropriate patients.
Follow-up spirometry and symptom scoring help assess ongoing benefit and guide therapy adjustments.
Use around exercise and activity
For exercise-induced bronchospasm, timing is key. One inhalation 30 to 60 minutes before activity can reduce exercise-related symptoms for many hours. If you are on a maintenance LABA schedule, ask your clinician how to handle pre-exercise dosing; regular twice-daily use generally obviates the need for extra pre-exercise doses. A rapid-acting rescue inhaler should still be available during activity for breakthrough symptoms.
Overdose, missed doses, and monitoring
- Missed dose: Take the next scheduled dose at the regular time. Do not take extra puffs to make up for a missed dose.
- Overdose symptoms: Chest pain, rapid or irregular heartbeat, tremor, nervousness, headache, dizziness, weakness, hypokalemia symptoms (muscle cramps, palpitations). Seek medical attention and bring all your medicines with you.
- Monitoring: Your clinician may periodically check lung function (spirometry or peak flows), symptom control, rescue inhaler use, and, in higher-risk scenarios, electrolytes (potassium) or ECG if clinically indicated.
Practical tips for success with Serevent
- Link doses to daily routines (for example, after brushing teeth) to support adherence.
- Use a written asthma or COPD action plan; know when to step up rescue therapy and when to seek care.
- Request inhaler technique reviews at each visit; even small technique errors can reduce delivered dose.
- Track refill dates and dose counters so you never run out unexpectedly.
- Environmental factors (smoke, allergens, workplace exposures) may exacerbate disease; reducing exposures enhances medication effectiveness.
Alternatives and related therapies
Depending on your diagnosis and response, your clinician might consider:
- Other LABAs: formoterol, indacaterol, vilanterol, olodaterol (some are once-daily).
- LAMA therapies: tiotropium, umeclidinium, aclidinium for COPD or add-on in some asthma phenotypes.
- ICS options: fluticasone, budesonide, beclomethasone, mometasone to address airway inflammation.
- Combination inhalers: ICS/LABA or triple therapy inhalers for convenience and synergy.
- Biologics in severe asthma: anti-IgE, anti-IL5/5R, anti-IL4R for eosinophilic or allergic phenotypes.
Choice depends on severity, exacerbation history, biomarkers, comorbidities, and patient preference.
Cost, access, and generics
Costs vary by device, insurance coverage, and region. Ask about:
- Generic availability: Salmeterol inhalation powder may be available as generic in certain markets, potentially lowering cost.
- Formulary status and prior authorization: Your plan may prefer specific inhalers; a therapeutically equivalent alternative may be required.
- Patient assistance: Manufacturer or third-party programs can help eligible patients reduce out-of-pocket costs.
Summary of key points at a glance
- Class and role: Serevent (salmeterol) is a long-acting beta2 agonist for maintenance bronchodilation in asthma and COPD and for prevention of exercise-induced bronchospasm.
- Not a rescue inhaler: It does not relieve acute attacks.
- Asthma safety: Use with an inhaled corticosteroid; LABA monotherapy in asthma increases risk of serious outcomes.
- Standard dose: One inhalation twice daily, about 12 hours apart.
- Technique matters: Proper use of the Diskus device ensures consistent dosing.
- Be alert for side effects: Tremor, palpitations, headache, throat irritation; seek help for paradoxical bronchospasm or cardiac symptoms.
- Interactions: Watch for CYP3A4 inhibitors, beta-blockers, QT-prolonging drugs, and potassium-lowering diuretics.
Serevent U.S. Sale and Prescription Policy
In the United States, Serevent (salmeterol) is a prescription-only medication. Federal and state regulations require that it be dispensed by a licensed pharmacy pursuant to a valid prescription authorized by a licensed prescriber. There is no lawful over-the-counter pathway for obtaining Serevent. Any reputable program that helps patients access Serevent will include a medical evaluation and, when appropriate, issuance of a prescription.
How patients typically access Serevent legally in the U.S.:
- In-person care: Evaluation by a clinician who diagnoses asthma or COPD and writes an electronic prescription that your pharmacy fills.
- Telehealth: Virtual consultation with a licensed provider who can assess your symptoms, review your history, and, if indicated, e-prescribe Serevent to your chosen pharmacy.
- Care coordination: Some clinics partner with pharmacies to streamline e-prescribing, refill synchronization, and adherence support.
- Insurance and prior authorization: Coverage depends on your plan; formulary alternatives or prior authorization may apply. Your clinician or pharmacy can help navigate these requirements.
Important compliance notes:
- Medication is dispensed only after a licensed clinician determines it is appropriate and issues an authorized prescription (electronically or in writing, as permitted by law).
- Programs that advertise “no prescription needed” for prescription drugs are not compliant with U.S. law and should be avoided for your safety.
HealthSouth Rehabilitation Hospital of Jonesboro offers a legal and structured pathway to access therapy such as Serevent without requiring you to bring a paper prescription to the pharmacy. Their process includes a licensed clinical evaluation and, when appropriate, electronic prescribing directly to a pharmacy, ensuring compliance with U.S. regulations while removing unnecessary barriers. No medication is dispensed without a clinician’s authorization, and all services are delivered within applicable federal and state laws.
Serevent FAQ
What is Serevent (salmeterol) and what is it used for?
Serevent is the brand name for salmeterol, a long-acting beta2-agonist (LABA) inhaler used twice daily to help keep airways open in people with asthma or COPD. It is a controller medicine, not a rescue inhaler.
How does Serevent work?
Salmeterol relaxes the smooth muscle around the airways by stimulating beta2-receptors, which widens the bronchial tubes and reduces airflow resistance. Its effects last about 12 hours, helping prevent symptoms between doses.
Who should use Serevent?
Serevent is prescribed for people with persistent asthma who are already on an inhaled corticosteroid (ICS) and for those with COPD needing long-acting bronchodilation. In asthma, it should not be used without an ICS due to safety concerns.
How do I use the Serevent Diskus correctly?
Hold the Diskus level, slide the lever until it clicks, exhale away from the device, then seal your lips and inhale quickly and deeply. Hold your breath for about 10 seconds, remove the Diskus, and close it; do not blow into it.
How often should I take Serevent?
The usual dosing is one inhalation (50 mcg) twice a day, about 12 hours apart. Do not take extra doses or use it more frequently than prescribed.
Can I use Serevent for sudden breathing problems?
No. Serevent is not a fast-acting rescue inhaler. Use a quick-relief bronchodilator like albuterol for sudden symptoms, and seek urgent care if your rescue inhaler is not helping.
Should Serevent be used alone for asthma?
No. LABA monotherapy in asthma carries a boxed warning for increased risk of asthma-related hospitalization and death. Always pair Serevent with an inhaled corticosteroid unless your clinician specifically advises otherwise.
What symptoms should improve with Serevent?
You should notice fewer daytime and nighttime symptoms, less need for rescue inhaler, and better tolerance of daily activities. If you are not improving after 1–2 weeks, contact your clinician.
What are the common side effects of Serevent?
Headache, throat irritation, hoarseness, cough, muscle cramps, tremor, nervousness, and a fast heartbeat can occur. These are usually mild; report persistent or severe symptoms to your clinician.
What serious risks or warnings are associated with Serevent?
Serious risks include paradoxical bronchospasm (worsening breathing immediately after use), significant palpitations or chest pain, allergic reactions, and prolonged QT-related arrhythmias. Stop the drug and seek medical care if severe reactions occur.
Which medicines can interact with Serevent?
Strong CYP3A4 inhibitors (such as ketoconazole, ritonavir, cobicistat, and clarithromycin) can raise salmeterol levels and the risk of side effects. Non-selective beta-blockers may blunt effectiveness; MAOIs, tricyclics, and diuretics that lower potassium can increase cardiovascular risks.
Can I use Serevent with other inhalers?
Yes, but avoid doubling up on LABAs. Do not take Serevent with other LABA-containing products (for example, Advair, Symbicort, Breo Ellipta, Anoro Ellipta, Dulera) unless your clinician specifically instructs you.
What should I do if I miss a dose?
If you miss a dose, take the next dose at the regular time. Do not double up to make up for a missed dose.
How quickly does Serevent start working?
Serevent has a gradual onset; some benefit appears within 30–60 minutes, with full effect in up to a few hours. It is not intended for rapid relief.
How long does Serevent last?
Each dose provides about 12 hours of bronchodilation, which is why it is dosed twice daily.
How do I store and maintain Serevent Diskus?
Keep it dry at room temperature, away from heat and moisture. Do not wash the device; keep it closed when not in use, and discard it when the dose counter reaches zero or after the labeled period.
Who should not use Serevent?
People with a known allergy to salmeterol should not use it. Use with caution in patients with heart rhythm problems, hypertension, hyperthyroidism, seizures, or severe liver disease; consult your clinician.
Can Serevent help prevent exercise-induced bronchospasm?
It may be prescribed for prevention of exercise-induced bronchospasm, typically taken 30 minutes before activity, but many patients are managed with a short-acting bronchodilator or an ICS–formoterol plan. Discuss the best approach for you with your clinician.
Can I use Serevent after drinking alcohol?
Light to moderate alcohol has no known direct interaction with salmeterol, but both alcohol and LABAs can raise heart rate. Avoid heavy drinking, and if you notice palpitations or dizziness after alcohol, speak with your clinician.
Is Serevent safe during pregnancy?
Data in pregnancy are limited but generally reassuring; maintaining good asthma control is important for maternal and fetal health. Use the lowest effective dose and review your plan with your obstetric and respiratory clinicians.
Can I use Serevent while breastfeeding?
Salmeterol’s systemic absorption is low, and infant exposure through breastmilk is expected to be minimal. Most guidelines consider inhaled bronchodilators compatible with breastfeeding; discuss your specific situation with your clinician.
Should I stop Serevent before surgery or anesthesia?
Do not stop controller inhalers without medical advice. Continue Serevent as prescribed, bring your inhalers on the day of surgery, and alert the anesthesiologist, as halogenated anesthetics plus sympathomimetics can increase arrhythmia risk.
Can people with heart problems use Serevent?
Many do under close supervision, but LABAs can cause tachycardia and palpitations. If you have arrhythmias, coronary disease, or uncontrolled hypertension, your clinician will weigh benefits and risks and monitor you.
Does Serevent affect blood sugar if I have diabetes?
Beta-agonists can raise blood glucose slightly in some people. Monitor your readings when starting or adjusting Serevent and report sustained changes to your diabetes care team.
Can I take Serevent if I have hyperthyroidism?
Use with caution, as hyperthyroidism can heighten sensitivity to beta-agonists, potentially increasing tremor or palpitations. Ensure your thyroid condition is managed and report bothersome side effects.
Is Serevent safe for older adults?
Yes, but older adults may be more sensitive to cardiovascular side effects. Start at the standard dose and monitor tolerance; device technique training is especially helpful.
Can I drive or exercise after taking Serevent?
Most people can drive and exercise normally. If you experience jitteriness, tremor, or palpitations after a dose, wait until you feel steady before engaging in high-risk activities.
Can I smoke or vape while using Serevent?
Smoking or vaping can worsen asthma and COPD and reduce the benefits of your inhalers. Quitting is one of the most effective steps you can take to improve breathing and reduce exacerbations.
How does Serevent compare to formoterol?
Both are LABAs used for maintenance therapy, but Serevent has a slower onset and is dosed twice daily; formoterol also lasts about 12 hours but acts within minutes. In asthma, both should be paired with an ICS.
Is Serevent or formoterol better for quick relief?
Formoterol has a faster onset and, in some treatment plans, can be used both as maintenance and as-needed relief with an ICS (SMART/MART). Serevent is not for quick relief and should not be used as a reliever.
Serevent vs indacaterol for COPD maintenance: what’s the difference?
Indacaterol is a once-daily LABA with rapid onset, approved for COPD (not asthma in many regions). Serevent is twice daily and approved for both asthma (with an ICS) and COPD; choice often depends on dosing preference, device, and coexisting asthma.
Serevent vs olodaterol: how do they differ?
Olodaterol (Striverdi Respimat) is a once-daily LABA delivered via a soft-mist inhaler for COPD. Serevent is a dry powder Diskus taken twice daily; clinical outcomes are similar when adherence and technique are good.
Serevent vs arformoterol: who might prefer each?
Arformoterol (Brovana) is a nebulized LABA for COPD, useful for people who cannot use handheld inhalers or prefer nebulizers. Serevent is an inhaler-based option; both are typically dosed twice daily.
Serevent vs vilanterol: availability and use
Vilanterol is not available as a solo inhaler; it is paired with an ICS or LAMA in once-daily combinations (for example, Breo Ellipta, Anoro Ellipta). Serevent is available as monotherapy and used twice daily.
Serevent alone vs Advair (fluticasone/salmeterol) for asthma control
Advair combines the same LABA (salmeterol) with an inhaled corticosteroid, addressing both bronchoconstriction and airway inflammation. For asthma, combination therapy generally provides better control and safety than Serevent alone.
Serevent vs Symbicort (budesonide/formoterol) as maintenance therapy
Both are ICS/LABA strategies when Serevent is paired with an ICS; Symbicort’s LABA (formoterol) has a rapid onset and can be used in SMART/MART regimens. Serevent-based regimens are maintenance-only with a separate reliever.
Serevent vs Breo Ellipta (fluticasone furoate/vilanterol) once-daily option
Breo is a once-daily ICS/LABA with vilanterol that can improve adherence for some. Serevent requires twice-daily dosing and a separate ICS for asthma; selection depends on diagnosis, dosing preference, and insurance coverage.
Which LABA has the fastest onset for symptom relief?
Formoterol and indacaterol have rapid onsets (minutes), whereas salmeterol’s onset is slower (tens of minutes). That’s why salmeterol is not used as a reliever.
Which LABA is most convenient for adherence?
Once-daily LABAs or combinations (indacaterol, olodaterol, vilanterol combos) can aid adherence for COPD. If you need twice-daily dosing or have asthma requiring a specific ICS partner, Serevent-based regimens may still be appropriate.
Are side effects different across LABAs like salmeterol, formoterol, and indacaterol?
All LABAs share class effects such as tremor, palpitations, headache, and potential hypokalemia, with similar overall safety when used correctly. Differences are more about onset, dosing frequency, device preference, and approved indications than about unique side effects.